The rappers have recorded over a dozen songs together over the last two decades.
Eminem has offered his two cents on a potential collaboration album with another legendary rapper.
The “Lose Yourself” musician was asked how he’d feel about recording a full album alongside 50 Cent during an interview with SiriusXM’s Whoo’s House Podcast on Wednesday. “That would be great,” Eminem opined. “I mean, I think that we just got to stop bulls—ting and just do it.”

He added, “I would never say it’s not possible, s—!”
The two rappers’ careers have been closely linked since they shot to superstardom in the late ’90s and early 2000s. Eminem initially signed 50 Cent to his Shady Records label after hearing the latter musician’s 2002 mixtape Guess Who’s Back?, and 50 Cent contributed four songs to the 8 Mile soundtrack the same year. Eminem then executive produced 50 Cent’s 2003 debut album Get Rich or Die Tryin’ and was featured on two tracks, “Patiently Waiting” and “Don’t Push Me.”
The duo later recorded numerous other songs together, including “Encore,” “Hail Mary,” “Gatman and Robin,” “Crack a Bottle,” “The Re-Up,” “You Don’t Know,” “Jimmy Crack Corn,” “Peep Show,” “Never Enough,” “My Life,” “Is This Love (’09),” and “Psycho.”
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Eminem at 50 Cent’s Hollywood Walk of Fame ceremony in 2020.Axelle/Bauer-Griffin/FilmMagic
Eminem and 50 Cent have also been co-featured on a number of other artists’ songs, including Obie Trice’s “We All Die One Day,” Lloyd Banks’ “Warrior, Pt. 2,” Ed Sheeran’s “Remember the Name,” and, most recently, Snoop Dogg’s “Gunz n Smoke.”
50 Cent also performed live with Eminem on several occasions, including on The Home & Home Tour in 2010 and at Eminem’s co-headlining Super Bowl halftime show in 2019.
The duo’s collaborations aren’t just relegated to the recording booth and the stage, either. In 2021, 50 Cent directed an episode of his Starz series BMF that featured Eminem in a cameo appearance as White Boy Rick. “When Eminem found out I was directing, he committed to do it, and working together was natural,” 50 told Entertainment Weekly at the time. “It was an honor to have him on the show and it made this episode extra special.”

Additionally, last year, 50 Cent said that the two musicians are “in motion” developing a “modern version” of 8 Mile for the small screen. “It’s gonna be big,” he teased. “I think it should be there for his legacy, because if you don’t see… it’s important to me that they understand it.”
Elsewhere in the Whoo’s House interview, Eminem said that unlike Jake Paul, he wouldn’t stand a chance fighting Mike Tyson, despite his reverence for the boxer. “That guy would hit me one time and I’d f—in’ die so I guess that’s it, so yeah so I’m down,” he said. “I’m down to fight Mike Tyson if he can’t hit me.”
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