John Cena is stepping into a new comedy role in Netflix’s upcoming film Little Brother, where he’s paired with Eric André in a story about what happens when a carefully controlled life is thrown off course by the one person you can’t plan for.

At the centre of the film, Cena plays a successful, image-conscious real estate agent who has built a tightly ordered world around himself.

That balance is quickly undone when his estranged younger brother, played by André, suddenly reappears, bringing along unpredictability. What follows is a clash of lifestyles, with structure on one side and chaos on the other.

Directed by Matt Spicer, best known for Ingrid Goes West, the film continues his focus on character-driven comedy with an edge. The screenplay comes from Jarrad Paul and Andrew Mogel, the writing duo behind The D-Train.

Meanwhile, David Bernad of Middle Child Pictures handles production alongside Ruben Fleischer. The result is a project rooted in strong comedic experience both in front of and behind the camera.

The cast expands beyond its central pairing, bringing in Michelle Monaghan, Sherry Cola, Christopher Meloni, Ego Nwodim and Caleb Hearon. Together, they add depth to the wider story, which moves between domestic settings and heightened comedic situations.

Early footage suggests a mix of physical comedy and awkward, emotionally charged exchanges that build on the sibling dynamic at the heart of the film.

Little Brother leans into a familiar idea — family doesn’t come with a choice, even when it turns life upside down. Cena’s character represents control and precision, while André’s brings disorder and spontaneity, with much of the humour coming from how those two worlds collide.

The film will stream globally on Netflix from June 26, 2026, positioning it as one of the platform’s key comedy releases for the summer slate.