A single vehicle crash has killed one man and left five injured.

NSW Police were called to Stuart Road at Dharruk, in west Sydney, shortly before 5.20pm on Sunday following reports an SUV had crashed into a residential property and was stuck in a tree.

One man, believed to be a passenger, was found partially ejected from the vehicle and died at the scene.

Two men, a woman and two toddlers were rushed to Westmead Hospital and The Children’s Hospital at Westmead by road ambulance.

‘The adults are reported to be in a serious but stable condition while the children, believed to be boys, are stable,’ NSW Police said in a statement.

Officers attached to Mount Druitt Police Area Command established a crime scene which specialist officers attached to the Crash Investigation Unit are attending.

It’s understood seatbelt usage will form part of the investigation.

Anyone with information or dashcam footage of the crash is urged to contact Crime Stoppers.

A car crashed into a property in Dharruk

The car became stuck in a tree after leaving the road

One man, believed to be a passenger, died and five other were injured