The death of Caroline Kennedy’s 35-year-old daughter Tatiana Schlossberg from cancer leaves John F. Kennedy’s only surviving child facing yet another tragedy in a life beset by heartache.

Kennedy, 68, was just five years old when her father died from an assassin’s bullet during a presidential motorcade in Dallas, Texas, in 1963.

Five years later, her uncle Robert Kennedy too would die tragically, assassinated while campaigning for president in Los Angeles in 1968.

In 1994 she lost her mother, Jacqueline Kennedy Onassis, to lymphoma at age 64.

The so-called ‘Kennedy curse’ reared its head yet again with the death of her brother, John F Kennedy Jr., in 1999.

JFK Jr, who was Caroline’s only sibling, died when a small plane he was piloting crashed near Martha’s Vineyard. He was only 38. His wife, Carolyn Bessette-Kennedy also perished in the crash alongside her sister Lauren.

The incident left Caroline the only remaining survivor of President Kennedy’s immediate family, and after years of heartbreak, she elected to not hold a public memorial service.

Instead, she scattered his ashes into the stretch of the Atlantic off the coast of Martha’s Vineyard where her brother met his fate.

At the time, Caroline was only 41. She was in the midst of building her own family, with longtime husband and Manhattan artist Edwin Schlossberg.

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Tatiana Schlossberg (left), passed away Tuesday morning at age 35, weeks after revealing she was diagnosed with terminal cancer last year. She is seen with her mother Caroline Kennedy in Manhattan as a teen in 2006

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Kennedy – a former US diplomat – is seen here with (l-r) sister-in-law Carolyn Bessette-Kennedy, brother JFK Jr, and husband Edwin Schlossberg. Both her brother and Bessette-Kennedy died in their 30s during a plane crash in 1999

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Kennedy also lost her mother, Jacqueline Kennedy Onassis, to lymphoma at age 64. She is seen alongside her brother at their mother’s 1994 funeral

After marrying in 1986, the two welcomed three children: Rose Schlossberg, 37; Tatiana, and youngest Jack, who is 32.

Tatiana would later become a successful journalist, writing for publications like The New York Times, The Atlantic, The Washington Post, Vanity Fair, and Bloomberg over the years.

Her mother, meanwhile, was named the US’s ambassador to Japan by then-President Barack Obama – a position she held until Donald Trump’s first term. She also served on both of Obama’s election campaigns.

Following Trump’s election loss to Joe Biden, she was named an ambassador again – this time for Australia.

In September 2024, she revealed she would be leaving her ambassadorial position regardless of the result of the presidential election.

In late November 2025, Tatiana revealed she had already been diagnosed with acute myeloid leukemia, a type of blood cancer, at the time.

She made the disclosure in an essay for The New Yorker titled ‘A Battle With My Blood’, where she detailed how doctors found the disease through routine blood tests following the birth of her second child last in May 2024.

‘It could just be something related to pregnancy and delivery, the doctor said, or it could be leukemia,’ the mother-of-two wrote.

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Kennedy is seen here alongside her late daughter Tatiana at her brother’s funeral in 1999. Tatianai – a successful journalist – passed away Tuesday night

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Two-year-old Caroline is pictured with her parents John F. Kennedy and Jacqueline Kennedy in Hyannisport, Massachusetts, in July 1960, three years before her father’s murder

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Caroline was just five years old when her father died from an assassin’s bullet during a presidential motorcade in Dallas, Texas, in 1963

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Caroline lost her uncle Robert to assassination as well in 1968. The New York senator seen here in New York marching in the city’s St. Patrick Day parade earlier that year

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Caroline was said to be extremely close to her late brother. The two are seen together at an event in Manhattan a year before his death

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Tatiana was diagnosed with a rare form of lymphoma in May 2024. Aside from her mother, she leaves behind a husband and two children, who mourned her on Tuesday

She spent five weeks at Columbia-Presbyterian Hospital after giving birth before being transferred to Memorial Sloan Kettering for a bone-marrow transplant, she said.

The disease was resistant to standard chemotherapy, as well a clinical trial of CAR-T-cell therapy – a type of immunotherapy against certain blood cancers, Tatiana said.

She also condemned her cousin RFK Jr.’s anti-vaccine rhetoric, calling the health secretary ‘mostly an embarrassment to me and the rest of my immediate family’.

An unfortunate update from the JFK Library Foundation’s social media accounts came on Tuesday.

‘Our beautiful Tatiana passed away this morning. She will always be in our hearts,’ it read.

The note was signed by Caroline, her husband, their kids, and other members of the Kennedy family.