Two people have died and six others have been rushed to hospital after a minivan flipped on a remote highway in South Australia.

A local paramedic called Triple-Zero about 5.30 this morning after witnessing a Toyota Tarago crash on the Horrocks Highway at Tarlee, about one hour north of Adelaide.

Two passengers were killed in the single vehicle crash, after it lost control and flipped, landing on its roof.

The Tarago lost control and rolled around 5.30 this morning. (Nine)

Six other occupants, including the driver, were rushed to hospital by road and air ambulance.

The small community of Tarlee is still healing from a fatal crash only two weeks ago, one of several across the state this festive season.

“We had a recent tragedy in the town with a family and we know first-hand how devastating that is,” local Michelle Warner said.

“[It’s] devastating, especially for the families involved and the people involved.”

Locals say the highway is a major thoroughfare mainly used for trucks and have been calling for safety upgrades for years.

“I’ve lived here for 90 years, just about, but the roads, there’s not enough spent on them for the amount of traffic that’s being used with heavy trucks and things these days,” Gavin Dunn said.

The highway was closed for several hours as major crash investigators probed the circumstances surrounding the crash. (Nine)

“There are some really bad black spots, bumps in the road,” Warner said.

“I’ve followed caravans up the road jumping over the bumps behind the vehicles.”

The highway remained closed for most of the day, with the Tarago towed from the scene this afternoon.

With the fatal crash bringing SA’s 2025 road toll to 87 lives lost, emergency services have urged road users to plan their journeys safely in the new year.

“All of the major contributors to road trauma you can control, so plan your trip, take responsibility, keep us all safe on the road,” SA Police assistant commissioner Stuart McLean said.

The circumstances surrounding the crash are yet to be determined.