Six people have been injured in a three-vehicle crash involving a stolen car in an affluent Brisbane suburb.

The three cars — a stolen Land Rover, a Mazda CX-60, and a Toyota Hiace — crashed on Kingsford Smith Dr near Cooksley St in Hamilton just before 4.30am on Tuesday.

Police said the Land Rover was reported stolen from a home in Beverley Cr in Broadbeach Waters on Monday night.

A 17-year-old Capalaba boy, a 16-year-old Rochedale South boy, a 16-year-old Loganholme boy and a 14-year-old Upper Mount Gravatt girl were all believed to be the occupants of the stolen Land Rover.

They were taken into custody a short distance away from the crash, and all four were taken to hospital under police guard with minor injuries.

Queensland Ambulance Service said a man in his 20s from one of the other cars involved in the crash, believed to be the Mazda, sustained serious leg injuries and was initially trapped in the wreckage before being freed.

Another man in the car, also believed to be in his 20s, was taken in a stable condition to hospital with cuts and chest pain.

The single occupant of the Toyota, a 41-year-old Spring Mountain man, did not sustain physical injuries, police said.

“Parts of Kingsford Smith Drive will remain closed this morning while investigations are ongoing,” they said.

“Investigators from both the Hendra Criminal Investigation Branch and Brisbane Forensic Crash Unit are investigating the circumstances of the incident and are appealing for anyone with relevant information or vision to come forward.”