The family of two girls who have died in hospital following a house fire in Townsville in North Queensland on the weekend say there are no words to describe the pain of losing them.

Evie, 13 and Hallie, two, were pulled from the burning two-storey home on Gum Court in Bushland Beach by first responders early on Sunday morning.

The girls were taken to Townsville University Hospital in a critical condition, where they died yesterday from their injuries.

Hallie, two and Evie, 13 have died days after they were pulled from their burning home with critical injuries. (Supplied)

A statement released by the girls’ family said they were devastated to confirm the girls had “passed away, surrounded by loved ones”.

“There are no words to describe the pain being experienced by the girls’ parents, Karah and Zac,” the statement said.

“Both parents would like to thank friends, extended family and the wider community for the care, compassion and support shown during this incredibly difficult time.

“As the family grieves and supports their other children and loved ones, they kindly ask that their privacy is respected.

“Thank you for your understanding and kindness.”

The home in Bushland Beach was destroyed by the fire. (Nine)

A fundraising page has been set up to support the girls’ mother Karah, a nurse and single mother-of-four.

Two teenage boys were able to escape the fire.

The investigation into the circumstances of the fire is ongoing, but it is being treated as non-suspicious.

Anybody with informaton is urged to contact police.